Which statement best describes the primary outcome of wet granulation in tablet formulation?

• A. Improves flow properties
• B. Reduces drying time
• C. Destroys drug potency
• D. Increases moisture sensitivity of all drugs

Answer: (D)

Wet granulation is used to turn a fine, free-flowing powder into larger, cohesive granules by adding a small amount of liquid binder. The main goal of this process is to improve the flowability and the compressibility of the powder, which helps achieve uniform content and weight in every tablet. When granules have more uniform size and density, they pack more consistently and reduce segregation during handling and tablet formation.

That’s why the best description is improved flow properties. The other statements don’t capture the primary aim: drying time is not inherently reduced and can even increase due to the added moisture; potency is not guaranteed to be destroyed and isn’t the defining outcome of the method; and moisture sensitivity is not universally increased for all drugs—moisture risk is an important consideration, but not the intended primary effect of the granulation itself.