What is an advantage of wet granulation?

• A. Improves flow properties
• B. Increases moisture sensitivity to unstable drugs
• C. Eliminates the need for drying
• D. Reduces compressional properties

Answer: (A)

Wet granulation forms granules by adding a binder liquid to powder, creating larger, more uniform particles. This reduces interparticle friction and cohesive forces, so the material flows much more readily from hoppers and into dies, leading to smoother and more uniform die filling and better content uniformity in the final tablet. That improvement in flow properties is the key advantage here, because consistent filling and dosing rely on good flow.

The other statements don’t fit as advantages. Introducing moisture in the process can pose stability risks for moisture-sensitive drugs, and the method actually requires a drying step after granulation, not eliminates it. As for compressional behavior, granulation typically improves tabletability rather than reducing it, so a claim that it reduces compressional properties isn’t accurate.