Buccal tablets are placed under the tongue and are subject to first-pass metabolism.

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Multiple Choice

Buccal tablets are placed under the tongue and are subject to first-pass metabolism.

Explanation:
The main idea is that absorption through the oral mucosa bypasses the liver’s first-pass metabolism. Buccal (and sublingual) administration delivers the drug directly into the systemic circulation via the buccal/sublingual mucosa, so it does not go through the hepatic portal system first. Therefore, the claim that buccal tablets are subject to first-pass metabolism is false. If the tablet is swallowed and the drug is absorbed from the GI tract, then first-pass metabolism can occur, but that would be due to GI absorption, not buccal absorption.

The main idea is that absorption through the oral mucosa bypasses the liver’s first-pass metabolism. Buccal (and sublingual) administration delivers the drug directly into the systemic circulation via the buccal/sublingual mucosa, so it does not go through the hepatic portal system first. Therefore, the claim that buccal tablets are subject to first-pass metabolism is false. If the tablet is swallowed and the drug is absorbed from the GI tract, then first-pass metabolism can occur, but that would be due to GI absorption, not buccal absorption.

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